| Date | Game | Units | Line | Outcome | |
| 12/31/2021 | Georgia @ Michigan | 4 | Michigan +7.5 (-110) | Loss (-440) | |
| 12/30/2021 | Wisconsin @ Arizona State | 2 | Wisconsin -6 (-110) | Win (+200) | |
| 12/29/2021 | Oregon @ Oklahoma | 3 | Oregon +7 (-115) | Loss (-345) | |
| 12/28/2021 | Mississippi State @ Texas Tech | 5 | Over 58.5 (-110) | Loss (-550) | |
| 12/27/2021 | Western Michigan @ Nevada | 5 | Nevada +7 (-110) | Loss (-550) | |
| 12/25/2021 | Georgia State @ Ball State | 4 | Over 53.5 (-110) | Win (+400) | |
| 12/25/2021 | Georgia State @ Ball State | 4 | Georgia State -6.5 (-110) | Win (+400) | |
| 12/23/2021 | North Texas @ Miami-OH | 5 | North Texas +2.5 (-110) | Loss (-550) | |
| 12/22/2021 | Missouri @ Army | 3 | Missouri +6.5 (-110) | Win (+300) | |
| 12/21/2021 | Kent State @ Wyoming | 3 | Over 59.5 (-110) | Win (+300) | |
| 12/20/2021 | Old Dominion @ Tulsa | 4 | Over 55 (-110) | Loss (-440) | |
| 12/18/2021 | Louisiana-Lafayette @ Marshall | 2 | Over 55 (-115) | Win (+200) | |
| 12/18/2021 | UTEP @ Fresno State | 4 | Fresno State -13 (-110) | Loss (-440) | |
| 12/18/2021 | WKU @ Appalachian State | 2 | Under 66.5 (-110) | Loss (-220) | |
| 12/17/2021 | Middle Tennessee @ Toledo | 1 | Over 49.5 (-110) | Win (+100) | |
| 12/04/2021 | Michigan @ Iowa | 5 | Michigan -11 (-110) | Win (+500) | |
| 12/04/2021 | Utah State @ San Diego State | 3 | San Diego State -6 (-110) | Loss (-330) | |
| 12/04/2021 | Utah State @ San Diego State | 4 | Under 49.5 (-110) | Loss (-440) | |
| 12/03/2021 | WKU @ UTSA | 1 | UTSA +3 (-110) | Win (+100) | |
| 12/03/2021 | WKU @ UTSA | 2 | Over 73 (-110) | Win (+200) | |
| 11/27/2021 | West Virginia @ Kansas | 3 | Over 55.5 (-110) | Win (+300) | |
| 11/27/2021 | Texas A&M @ LSU | 3 | Texas A&M -6.5 (-115) | Loss (-345) | |
| 11/27/2021 | LA Tech @ Rice | 5 | Over 53 (-105) | Win (+500) | |
| 11/27/2021 | Miami-FL @ Duke | 2 | Miami-FL -21.5 (-110) | Win (+200) | |
| 11/27/2021 | Maryland @ Rutgers | 5 | Rutgers +1.5 (-110) | Loss (-550) | |
| 11/27/2021 | Georgia @ Georgia Tech | 3 | Georgia -36 (-110) | Win (+300) | |
| 11/27/2021 | Texas Tech @ Baylor | 2 | Over 51.5 (-110) | Loss (-220) | |
| 11/26/2021 | Colorado @ Utah | 1 | Utah -23.5 (-115) | Loss (-115) | |
| 11/26/2021 | Cincinnati @ East Carolina | 2 | East Carolina +14 (-105) | Loss (-210) | |
| 11/26/2021 | Missouri @ Arkansas | 1 | Over 63.5 (-110) | Loss (-110) | |
| 11/26/2021 | Iowa @ Nebraska | 2 | Iowa +1 (-110) | Win (+200) | |
| 11/26/2021 | Kansas State @ Texas | 2 | Kansas State +3 (-110) | Loss (-220) | |
| 11/25/2021 | Ole Miss @ Mississippi State | 3 | Mississippi State -1 (-110) | Loss (-330) | |
| 11/25/2021 | Ole Miss @ Mississippi State | 4 | Over 64 (-110) | Loss (-440) | |
| 11/23/2021 | Western Michigan @ NIU | 4 | NIU +3.5 (-105) | Loss (-420) | |
| 11/23/2021 | Western Michigan @ NIU | 2 | Over 58.5 (-105) | Win (+200) | |
| 11/20/2021 | Virginia Tech @ Miami-FL | 3 | Virginia Tech +7.5 (-110) | Loss (-330) | |
| 11/20/2021 | South Alabama @ Tennessee | 4 | Tennessee -28 (-110) | Win (+400) | |
| 11/20/2021 | California @ Stanford | 2 | Stanford +2 (-110) | Loss (-220) | |
| 11/20/2021 | Baylor @ Kansas State | 5 | Kansas State -1 (-105) | Loss (-525) | |
| 11/20/2021 | Louisiana-Lafayette @ Liberty | 5 | Under 53.5 (-110) | Loss (-550) | |
| 11/20/2021 | Old Dominion @ Middle Tennessee | 4 | Old Dominion +4 (-115) | Win (+400) | |
| 11/20/2021 | Appalachian State @ Troy | 5 | Appalachian State -10 (-105) | Win (+500) | |
| 11/20/2021 | Iowa State @ Oklahoma | 1 | Oklahoma -3 (-115) | Win (+100) | |
| 11/20/2021 | Wofford @ North Carolina | 4 | Wofford +40.5 (-107) | Win (+400) | |
| 11/19/2021 | San Diego State @ UNLV | 1 | Under 41 (-110) | Loss (-110) | |
| 11/18/2021 | Louisville @ Duke | 4 | Over 60.5 (-110) | Win (+400) | |
| 11/18/2021 | Louisville @ Duke | 1 | Louisville -20.5 (-110) | Win (+100) | |
| 11/17/2021 | Central Michigan @ Ball State | 2 | Central Michigan -2.5 (-115) | Win (+200) | |
| 11/17/2021 | Central Michigan @ Ball State | 3 | Over 57 (-110) | Loss (-330) | |
| 11/16/2021 | Western Michigan @ Eastern Michigan | 5 | Over 68 (-110) | Loss (-550) | |
| 11/13/2021 | Notre Dame @ Virginia | 1 | Notre Dame -6.5 (-110) | Win (+100) | |
| 11/13/2021 | Maryland @ Michigan State | 3 | Over 60.5 (-110) | Win (+300) | |
| 11/13/2021 | Georgia @ Tennessee | 2 | Over 56 (-110) | Win (+200) | |
| 11/13/2021 | Louisiana-Lafayette @ Troy | 1 | Over 48 (-110) | Win (+100) | |
| 11/13/2021 | South Alabama @ Appalachian State | 5 | South Alabama +22.5 (-110) | Loss (-550) | |
| 11/13/2021 | South Alabama @ Appalachian State | 3 | Under 51.5 (-110) | Win (+300) | |
| 11/13/2021 | WKU @ Rice | 5 | Over 61.5 (-110) | Win (+500) | |
| 11/13/2021 | Utah @ Arizona | 2 | Under 54.5 (-110) | Loss (-220) | |
| 11/13/2021 | Mississippi State @ Auburn | 5 | Mississippi State +6 (-115) | Win (+500) | |
| 11/13/2021 | Syracuse @ Louisville | 4 | Louisville -3.5 (-105) | Win (+400) | |
| 11/13/2021 | Houston @ Temple | 4 | Houston -26 (-110) | Win (+400) | |
| 11/13/2021 | UCONN @ Clemson | 4 | Over 51 (-110) | Push (+0) | |
| 11/13/2021 | Northwestern @ Wisconsin | 1 | Over 41.5 (-110) | Win (+100) | |
| 11/12/2021 | Wyoming @ Boise State | 1 | Wyoming +13.5 (-110) | Win (+100) | |
| 11/10/2021 | Ball State @ NIU | 2 | Over 59.5 (-105) | Loss (-210) | |
| 11/09/2021 | Akron @ Western Michigan | 4 | Akron +26 (-110) | Win (+400) | |
| 11/06/2021 | San Diego State @ Hawaii | 5 | Over 45.5 (-110) | Loss (-550) | |
| 11/06/2021 | Clemson @ Louisville | 4 | Over 46.5 (-110) | Win (+400) | |
| 11/06/2021 | Oregon State @ Colorado | 1 | Under 54.5 (-110) | Loss (-110) | |
| 11/06/2021 | Coastal Carolina @ Georgia Southern | 2 | Coastal Carolina -18 (-110) | Win (+200) | |
| 11/06/2021 | Colorado State @ Wyoming | 3 | Colorado State -3.5 (-105) | Loss (-315) | |
| 11/06/2021 | Oklahoma State @ West Virginia | 2 | Oklahoma State -3.5 (-110) | Win (+200) | |
| 11/06/2021 | Michigan State @ Purdue | 3 | Purdue +3 (-110) | Win (+300) | |
| 11/06/2021 | Pittsburgh @ Duke | 5 | Pittsburgh -21.5 (-105) | Win (+500) | |
| 11/06/2021 | Pittsburgh @ Duke | 5 | Over 64 (-115) | Win (+500) | |
| 11/05/2021 | Utah @ Stanford | 4 | Utah -9 (-110) | Win (+400) | |
| 11/05/2021 | Virginia Tech @ Boston College | 5 | Under 51 (-105) | Win (+500) | |
| 11/03/2021 | NIU @ Kent State | 4 | Kent State -3 (-115) | Win (+400) | |
| 11/02/2021 | Eastern Michigan @ Toledo | 4 | Toledo -9 (-110) | Loss (-440) | |
| 10/30/2021 | Virginia @ BYU | 3 | Virginia +2.5 (-110) | Loss (-330) | |
| 10/30/2021 | UCLA @ Utah | 4 | Utah -6.5 (-110) | Win (+400) | |
| 10/30/2021 | Boise State @ Colorado State | 4 | Boise State -2.5 (-110) | Win (+400) | |
| 10/30/2021 | Oregon State @ California | 5 | Under 55.5 (-110) | Loss (-550) | |
| 10/30/2021 | Boston College @ Syracuse | 3 | Over 51 (-110) | Loss (-330) | |
| 10/30/2021 | Florida State @ Clemson | 1 | Clemson -9 (-110) | Win (+100) | |
| 10/30/2021 | Michigan @ Michigan State | 2 | Michigan -4 (-110) | Loss (-220) | |
| 10/30/2021 | Massachusetts @ Liberty | 2 | Liberty -35.5 (-110) | Win (+200) | |
| 10/29/2021 | Navy @ Tulsa | 4 | Tulsa -11 (-105) | Loss (-420) | |
| 10/23/2021 | Georgia Tech @ Virginia | 2 | Georgia Tech +6.5 (-110) | Loss (-220) | |
| 10/23/2021 | West Virginia @ TCU | 2 | West Virginia +5 (-110) | Win (+200) | |
| 10/23/2021 | Tennessee @ Alabama | 4 | Over 68 (-110) | Win (+400) | |
| 10/23/2021 | South Alabama @ Louisiana-Monroe | 1 | Louisiana-Monroe +13.5 (-110) | Win (+100) | |
| 10/23/2021 | Rice @ UAB | 5 | UAB -24 (-110) | Loss (-550) | |
| 10/23/2021 | Buffalo @ Akron | 2 | Buffalo -12.5 (-110) | Win (+200) | |
| 10/23/2021 | Cincinnati @ Navy | 5 | Over 49.5 (-115) | Loss (-575) | |
| 10/22/2021 | Memphis @ UCF | 3 | Memphis -1.5 (-110) | Loss (-330) | |
| 10/21/2021 | Tulane @ SMU | 4 | Over 70.5 (-110) | Win (+400) | |
| 10/21/2021 | Louisiana-Lafayette @ Arkansas State | 3 | Arkansas State +18 (-105) | Win (+300) | |
| 10/21/2021 | Florida Atlantic @ Charlotte | 1 | Over 58 (-115) | Loss (-115) | |
| 10/20/2021 | Coastal Carolina @ Appalachian State | 5 | Over 61 (-110) | Loss (-550) | |
| 10/16/2021 | LA Tech @ UTEP | 4 | UTEP +6.5 (-110) | Win (+400) | |
| 10/16/2021 | Stanford @ Washington State | 1 | Under 53 (-110) | Loss (-110) | |
| 10/16/2021 | NC State @ Boston College | 3 | Under 51 (-110) | Win (+300) | |
| 10/16/2021 | TCU @ Oklahoma | 1 | Under 64 (-115) | Loss (-115) | |
| 10/16/2021 | Troy @ Texas State | 3 | Troy -7.5 (-110) | Loss (-330) | |
| 10/16/2021 | Tulsa @ USF | 3 | Tulsa -8 (-110) | Loss (-330) | |
| 10/16/2021 | Florida @ LSU | 5 | Over 59.5 (-110) | Win (+500) | |
| 10/15/2021 | California @ Oregon | 2 | California +13.5 (-110) | Win (+200) | |
| 10/15/2021 | Clemson @ Syracuse | 2 | Over 43.5 (-115) | Loss (-230) | |
| 10/15/2021 | Clemson @ Syracuse | 3 | Clemson -13.5 (-105) | Loss (-315) | |
| 10/14/2021 | Georgia Southern @ South Alabama | 1 | Over 49.5 (-110) | Win (+100) | |
| 10/14/2021 | Georgia Southern @ South Alabama | 4 | Georgia Southern +3 (-105) | Loss (-420) | |
| 10/12/2021 | Appalachian State @ Louisiana-Lafayette | 4 | Over 57 (-110) | Loss (-440) | |
| 10/09/2021 | LSU @ Kentucky | 1 | Kentucky -2.5 (-110) | Win (+100) | |
| 10/09/2021 | Penn State @ Iowa | 1 | Under 41 (-110) | Loss (-110) | |
| 10/09/2021 | Oregon State @ Washington State | 5 | Oregon State -4 (-105) | Loss (-525) | |
| 10/09/2021 | Ball State @ Western Michigan | 5 | Ball State +11 (-110) | Win (+500) | |
| 10/09/2021 | SMU @ Navy | 1 | Under 55.5 (-110) | Win (+100) | |
| 10/09/2021 | UCONN @ Massachusetts | 3 | Over 57 (-110) | Loss (-330) | |
| 10/09/2021 | Old Dominion @ Marshall | 1 | Over 63.5 (-110) | Loss (-110) | |
| 10/09/2021 | Michigan State @ Rutgers | 2 | Over 51 (-115) | Loss (-230) | |
| 10/09/2021 | Maryland @ Ohio State | 2 | Over 71 (-115) | Win (+200) | |
| 10/08/2021 | Temple @ Cincinnati | 4 | Over 54 (-115) | Win (+400) | |
| 10/08/2021 | Temple @ Cincinnati | 5 | Cincinnati -29.5 (-110) | Win (+500) | |
| 10/07/2021 | Houston @ Tulane | 2 | Over 60 (-110) | Win (+200) | |
| 10/07/2021 | Houston @ Tulane | 2 | Houston -6.5 (-110) | Win (+200) | |
| 10/02/2021 | Arizona State @ UCLA | 4 | Under 56 (-110) | Loss (-440) | |
| 10/02/2021 | Auburn @ LSU | 1 | Auburn +3 (-110) | Win (+100) | |
| 10/02/2021 | Louisiana-Lafayette @ South Alabama | 4 | Under 53 (-115) | Win (+400) | |
| 10/02/2021 | Mississippi State @ Texas A&M | 4 | Mississippi State +7.5 (-115) | Win (+400) | |
| 10/02/2021 | Troy @ South Carolina | 4 | South Carolina -6.5 (-110) | Win (+400) | |
| 10/02/2021 | Louisiana-Monroe @ Coastal Carolina | 3 | Coastal Carolina -34 (-110) | Win (+300) | |
| 10/02/2021 | Cincinnati @ Notre Dame | 4 | Cincinnati -1.5 (-110) | Win (+400) | |
| 10/02/2021 | Toledo @ Massachusetts | 1 | Over 56.5 (-110) | Loss (-110) | |
| 10/02/2021 | Duke @ North Carolina | 2 | North Carolina -19.5 (-110) | Win (+200) | |
| 10/01/2021 | BYU @ Utah State | 4 | Over 61.5 (-110) | Loss (-440) | |
| 10/01/2021 | BYU @ Utah State | 4 | BYU -10 (-105) | Win (+400) | |
| 09/30/2021 | Virginia @ Miami-FL | 1 | Over 64 (-110) | Loss (-110) | |
| 09/25/2021 | California @ Washington | 1 | Washington -7.5 (-110) | Loss (-110) | |
| 09/25/2021 | Troy @ Louisiana-Monroe | 1 | Louisiana-Monroe +24 (-115) | Win (+100) | |
| 09/25/2021 | West Virginia @ Oklahoma | 3 | West Virginia +17 (-110) | Win (+300) | |
| 09/25/2021 | Kentucky @ South Carolina | 5 | South Carolina +5 (-110) | Loss (-550) | |
| 09/25/2021 | Kansas State @ Oklahoma State | 2 | Oklahoma State -5.5 (-110) | Win (+200) | |
| 09/25/2021 | UCLA @ Stanford | 4 | Over 62 (-110) | Loss (-440) | |
| 09/25/2021 | Iowa State @ Baylor | 5 | Over 46 (-110) | Win (+500) | |
| 09/25/2021 | Richmond @ Virginia Tech | 5 | Richmond +29 (-110) | Win (+500) | |
| 09/25/2021 | Georgia @ Vanderbilt | 3 | Over 54.5 (-110) | Win (+300) | |
| 09/24/2021 | UNLV @ Fresno State | 1 | Under 58.5 (-110) | Loss (-110) | |
| 09/24/2021 | Liberty @ Syracuse | 3 | Liberty -7 (-105) | Loss (-315) | |
| 09/23/2021 | Marshall @ Appalachian State | 1 | Over 59.5 (-110) | Win (+100) | |
| 09/18/2021 | Rice @ Texas | 4 | Under 52 (-110) | Loss (-440) | |
| 09/18/2021 | Stanford @ Vanderbilt | 3 | Stanford -13 (-105) | Win (+300) | |
| 09/18/2021 | Florida A&M @ USF | 1 | Over 50 (-110) | Win (+100) | |
| 09/18/2021 | Grambling State @ Houston | 4 | Houston -41 (-110) | Win (+400) | |
| 09/18/2021 | Middle Tennessee @ UTSA | 2 | Over 60 (-105) | Loss (-210) | |
| 09/18/2021 | Bryant @ Akron | 2 | Akron -14 (-115) | Win (+200) | |
| 09/18/2021 | Tulsa @ Ohio State | 4 | Ohio State -25 (-110) | Loss (-440) | |
| 09/18/2021 | Idaho @ Oregon State | 1 | Oregon State -28 (-110) | Win (+100) | |
| 09/18/2021 | LIU @ Miami-OH | 5 | Over 55.5 (-110) | Loss (-550) | |
| 09/18/2021 | Baylor @ Kansas | 2 | Kansas +18 (-115) | Loss (-230) | |
| 09/18/2021 | Boston College @ Temple | 5 | Boston College -15 (-105) | Win (+500) | |
| 09/11/2021 | Vanderbilt @ Colorado State | 4 | Over 51.5 (-110) | Loss (-440) | |
| 09/11/2021 | Howard @ Maryland | 2 | Over 56 (-115) | Win (+200) | |
| 09/11/2021 | Southern Illinois @ Kansas State | 4 | Over 55 (-115) | Loss (-460) | |
| 09/11/2021 | Memphis @ Arkansas State | 2 | Over 64.5 (-115) | Win (+200) | |
| 09/11/2021 | Texas @ Arkansas | 2 | Over 56.5 (-110) | Win (+200) | |
| 09/11/2021 | Air Force @ Navy | 5 | Over 40 (-105) | Loss (-525) | |
| 09/11/2021 | Georgia Southern @ Florida Atlantic | 2 | Over 49.5 (-110) | Loss (-220) | |
| 09/11/2021 | California @ TCU | 1 | Over 46.5 (-110) | Win (+100) | |
| 09/11/2021 | Duquesne @ Ohio | 4 | Duquesne +29 (-110) | Win (+400) | |
| 09/11/2021 | Norfolk State @ Wake Forest | 1 | Wake Forest -43 (-110) | Loss (-110) | |
| 09/11/2021 | South Carolina @ East Carolina | 4 | Over 56.5 (-110) | Loss (-440) | |
| 09/11/2021 | WKU @ Army | 4 | Over 52.5 (-110) | Win (+400) | |
| 09/10/2021 | Kansas @ Coastal Carolina | 5 | Over 53 (-105) | Win (+500) | |
| 09/04/2021 | Baylor @ Texas State | 2 | Baylor -13.5 (-110) | Loss (-220) | |
| 09/04/2021 | Southern University @ Troy | 3 | Over 55.5 (-110) | Win (+300) | |
| 09/04/2021 | Akron @ Auburn | 2 | Auburn -37.5 (-110) | Win (+200) | |
| 09/04/2021 | Oregon State @ Purdue | 1 | Over 68 (-110) | Loss (-110) | |
| 09/04/2021 | Temple @ Rutgers | 2 | Under 52 (-110) | Loss (-220) | |
| 09/04/2021 | Alabama @ Miami-FL | 2 | Alabama -19.5 (-110) | Win (+200) | |
| 09/04/2021 | Rice @ Arkansas | 5 | Arkansas -20 (-110) | Win (+500) | |
| 09/03/2021 | St. Francis-PA @ Eastern Michigan | 1 | Eastern Michigan -34.5 (-110) | Loss (-110) | |
| 09/02/2021 | UC Davis @ Tulsa | 5 | Tulsa -23.5 (-109) | Loss (-545) | |
| 09/01/2021 | UAB @ Jacksonville State | 5 | UAB -16 (+100) | Win (+500) | |
| 08/28/2021 | Southern Utah @ San Jose State | 5 | San Jose State -24.5 (-115) | Win (+500) | |
| 01/11/2021 | Ohio State Buckeyes @ Alabama Crimson Tide | 2 | Alabama Crimson Tide -8.75 (-110) | Win (+200) | |
| 01/02/2021 | Texas A&M @ North Carolina | 3 | Texas A&M -10 (-110) | Win (+300) | |
| 01/02/2021 | Oregon @ Iowa State | 4 | Oregon 5 (-110) | Loss (-440) | |
| 01/02/2021 | Ole Miss @ Indiana | 3 | Over 67.5 (-110) | Loss (-330) | |
| 01/01/2021 | Georgia @ Cincinnati | 3 | Georgia N/A (-110) | Win (+300) |