| Date | Game | Units | Line | Outcome | |
| 12/31/2021 | Cincinnati @ Alabama | 4 | Cincinnati +14 (-110) | Loss (-440) | |
| 12/31/2021 | Washington State @ Central Michigan | 5 | Washington State -7 (-115) | Loss (-575) | |
| 12/30/2021 | Pittsburgh @ Michigan State | 1 | Michigan State -3.5 (-105) | Win (+100) | |
| 12/30/2021 | North Carolina @ South Carolina | 5 | Under 57 (-110) | Loss (-550) | |
| 12/29/2021 | Clemson @ Iowa State | 4 | Under 44 (-110) | Win (+400) | |
| 12/29/2021 | Clemson @ Iowa State | 1 | Clemson -2.5 (-110) | Win (+100) | |
| 12/23/2021 | UCF @ Florida | 4 | Under 55.5 (-110) | Win (+400) | |
| 12/21/2021 | UTSA @ San Diego State | 1 | San Diego State -2.5 (-110) | Win (+100) | |
| 12/20/2021 | Old Dominion @ Tulsa | 4 | Over 55 (-110) | Loss (-440) | |
| 12/04/2021 | Michigan @ Iowa | 4 | Over 43.5 (-110) | Win (+400) | |
| 12/04/2021 | Houston @ Cincinnati | 5 | Cincinnati -10.5 (-105) | Win (+500) | |
| 11/27/2021 | Nevada @ Colorado State | 1 | Over 57 (-110) | Win (+100) | |
| 11/27/2021 | Notre Dame @ Stanford | 1 | Notre Dame -21 (-105) | Win (+100) | |
| 11/27/2021 | Kentucky @ Louisville | 3 | Kentucky +3 (-115) | Win (+300) | |
| 11/27/2021 | Texas State @ Arkansas State | 5 | Over 62 (-115) | Loss (-575) | |
| 11/27/2021 | LA Tech @ Rice | 3 | LA Tech -4 (-105) | Loss (-315) | |
| 11/27/2021 | Texas Tech @ Baylor | 2 | Over 51.5 (-110) | Loss (-220) | |
| 11/27/2021 | Navy @ Temple | 4 | Over 42.5 (-110) | Win (+400) | |
| 11/27/2021 | Akron @ Toledo | 5 | Akron +29 (-110) | Loss (-550) | |
| 11/26/2021 | Iowa @ Nebraska | 5 | Over 41 (-110) | Win (+500) | |
| 11/26/2021 | Utah State @ New Mexico | 4 | Over 48 (-110) | Loss (-440) | |
| 11/26/2021 | Eastern Michigan @ Central Michigan | 4 | Over 63.5 (-115) | Loss (-460) | |
| 11/20/2021 | UCONN @ UCF | 2 | Under 56 (-110) | Loss (-220) | |
| 11/20/2021 | Syracuse @ NC State | 4 | Over 49.5 (-110) | Win (+400) | |
| 11/20/2021 | Rice @ UTEP | 1 | Over 47 (-110) | Win (+100) | |
| 11/20/2021 | Virginia @ Pittsburgh | 1 | Over 67.5 (-110) | Win (+100) | |
| 11/20/2021 | Nebraska @ Wisconsin | 5 | Under 43.5 (-110) | Loss (-550) | |
| 11/20/2021 | SMU @ Cincinnati | 5 | Over 65.5 (-110) | Loss (-550) | |
| 11/20/2021 | Minnesota @ Indiana | 1 | Minnesota -7.5 (-110) | Win (+100) | |
| 11/20/2021 | Washington @ Colorado | 4 | Over 43 (-110) | Loss (-440) | |
| 11/20/2021 | Texas @ West Virginia | 1 | Over 56.5 (-110) | Loss (-110) | |
| 11/20/2021 | Prairie View @ Texas A&M | 3 | Over 50.5 (-110) | Win (+300) | |
| 11/19/2021 | Arizona @ Washington State | 3 | Over 52.5 (-110) | Win (+300) | |
| 11/19/2021 | Arizona @ Washington State | 2 | Arizona +15 (-110) | Loss (-220) | |
| 11/16/2021 | Western Michigan @ Eastern Michigan | 4 | Over 68 (-110) | Loss (-440) | |
| 11/16/2021 | Western Michigan @ Eastern Michigan | 3 | Eastern Michigan +5.5 (-110) | Win (+300) | |
| 11/13/2021 | Kansas @ Texas | 2 | Over 62 (-110) | Win (+200) | |
| 11/13/2021 | Air Force @ Colorado State | 4 | Over 45 (-110) | Win (+400) | |
| 11/13/2021 | Texas A&M @ Ole Miss | 1 | Texas A&M -2.5 (-115) | Loss (-115) | |
| 11/13/2021 | Stanford @ Oregon State | 1 | Oregon State -12.5 (-110) | Win (+100) | |
| 11/13/2021 | South Carolina @ Missouri | 3 | Missouri -1 (-110) | Win (+300) | |
| 11/13/2021 | UAB @ Marshall | 4 | Under 55 (-110) | Win (+400) | |
| 11/13/2021 | UAB @ Marshall | 1 | Marshall -4.5 (-110) | Loss (-110) | |
| 11/13/2021 | New Mexico State @ Alabama | 5 | Over 67 (-115) | Loss (-575) | |
| 11/13/2021 | Northwestern @ Wisconsin | 5 | Over 41.5 (-110) | Win (+500) | |
| 11/13/2021 | Oklahoma @ Baylor | 5 | Baylor +3.5 (-110) | Win (+500) | |
| 11/11/2021 | North Carolina @ Pittsburgh | 2 | Under 73 (-110) | Win (+200) | |
| 11/10/2021 | Ball State @ NIU | 5 | Over 59.5 (-105) | Loss (-525) | |
| 11/10/2021 | Ball State @ NIU | 2 | Ball State -3 (+100) | Loss (-200) | |
| 11/09/2021 | Ohio @ Eastern Michigan | 5 | Over 60.5 (-110) | Loss (-550) | |
| 11/06/2021 | USC @ Arizona State | 1 | Arizona State -8.5 (-115) | Win (+100) | |
| 11/06/2021 | UTSA @ UTEP | 3 | UTSA -11.5 (-110) | Win (+300) | |
| 11/06/2021 | San Jose State @ Nevada | 2 | Over 54.5 (-110) | Loss (-220) | |
| 11/06/2021 | UNLV @ New Mexico | 5 | Over 45 (-110) | Win (+500) | |
| 11/06/2021 | Marshall @ Florida Atlantic | 1 | Over 57.5 (-110) | Loss (-110) | |
| 11/06/2021 | Penn State @ Maryland | 1 | Maryland +10 (-110) | Loss (-110) | |
| 11/06/2021 | Penn State @ Maryland | 5 | Under 55.5 (-110) | Win (+500) | |
| 11/06/2021 | Wisconsin @ Rutgers | 4 | Over 38 (-110) | Win (+400) | |
| 11/06/2021 | LA Tech @ UAB | 3 | UAB -14 (-110) | Push (+0) | |
| 11/06/2021 | Ohio State @ Nebraska | 5 | Ohio State -15 (-115) | Loss (-575) | |
| 11/05/2021 | Utah @ Stanford | 4 | Under 54 (-110) | Loss (-440) | |
| 11/04/2021 | Georgia State @ Louisiana-Lafayette | 2 | Over 54 (-105) | Loss (-210) | |
| 11/02/2021 | Miami-OH @ Ohio | 1 | Over 54.5 (-105) | Win (+100) | |
| 11/02/2021 | Miami-OH @ Ohio | 4 | Miami-OH -7 (-110) | Loss (-440) | |
| 10/30/2021 | Washington @ Stanford | 1 | Under 46 (-105) | Win (+100) | |
| 10/30/2021 | Louisville @ NC State | 4 | Over 56.5 (-110) | Loss (-440) | |
| 10/30/2021 | Ole Miss @ Auburn | 5 | Auburn -3 (-110) | Win (+500) | |
| 10/30/2021 | Purdue @ Nebraska | 3 | Purdue +7.5 (-110) | Win (+300) | |
| 10/30/2021 | Missouri @ Vanderbilt | 5 | Missouri -16 (-110) | Loss (-550) | |
| 10/30/2021 | North Texas @ Rice | 1 | Over 55 (-115) | Loss (-115) | |
| 10/30/2021 | Iowa State @ West Virginia | 5 | West Virginia +7.5 (-110) | Win (+500) | |
| 10/30/2021 | Miami-FL @ Pittsburgh | 1 | Over 61 (-110) | Win (+100) | |
| 10/23/2021 | East Carolina @ Houston | 2 | Over 57 (-110) | Loss (-220) | |
| 10/23/2021 | Liberty @ North Texas | 4 | Over 61 (-110) | Push (+0) | |
| 10/23/2021 | Miami-OH @ Ball State | 5 | Over 52 (-105) | Loss (-525) | |
| 10/23/2021 | Western Michigan @ Toledo | 3 | Over 54.5 (-110) | Loss (-330) | |
| 10/23/2021 | Wisconsin @ Purdue | 2 | Under 40.5 (-110) | Loss (-220) | |
| 10/23/2021 | Illinois @ Penn State | 1 | Illinois +23 (-110) | Win (+100) | |
| 10/23/2021 | Oklahoma @ Kansas | 2 | Oklahoma -38.5 (-110) | Loss (-220) | |
| 10/23/2021 | Massachusetts @ Florida State | 5 | Florida State -35.5 (-110) | Win (+500) | |
| 10/22/2021 | Memphis @ UCF | 1 | Under 63 (-105) | Win (+100) | |
| 10/22/2021 | Middle Tennessee @ UCONN | 2 | Over 54 (-110) | Win (+200) | |
| 10/21/2021 | Louisiana-Lafayette @ Arkansas State | 2 | Over 70 (-105) | Loss (-210) | |
| 10/21/2021 | Tulane @ SMU | 2 | Tulane +14 (-110) | Loss (-220) | |
| 10/16/2021 | Arizona State @ Utah | 1 | Over 51 (-110) | Win (+100) | |
| 10/16/2021 | Army @ Wisconsin | 5 | Under 38.5 (-110) | Win (+500) | |
| 10/16/2021 | Texas Tech @ Kansas | 5 | Over 68 (-105) | Loss (-525) | |
| 10/16/2021 | BYU @ Baylor | 4 | Over 52.5 (-110) | Win (+400) | |
| 10/16/2021 | Bowling Green @ NIU | 3 | NIU -9 (-110) | Loss (-330) | |
| 10/16/2021 | Texas A&M @ Missouri | 2 | Texas A&M -11.5 (-110) | Win (+200) | |
| 10/16/2021 | Ohio @ Buffalo | 1 | Buffalo -7.5 (-110) | Loss (-110) | |
| 10/16/2021 | Oklahoma State @ Texas | 2 | Over 61.5 (-110) | Loss (-220) | |
| 10/15/2021 | Marshall @ North Texas | 3 | Marshall -11 (-110) | Win (+300) | |
| 10/15/2021 | Marshall @ North Texas | 2 | Over 66 (-110) | Win (+200) | |
| 10/12/2021 | Appalachian State @ Louisiana-Lafayette | 4 | Louisiana-Lafayette +5 (-110) | Win (+400) | |
| 10/09/2021 | New Mexico @ San Diego State | 5 | Over 42.5 (-110) | Loss (-550) | |
| 10/09/2021 | TCU @ Texas Tech | 5 | TCU -2.5 (-110) | Win (+500) | |
| 10/09/2021 | Middle Tennessee @ Liberty | 2 | Over 59 (-110) | Loss (-220) | |
| 10/09/2021 | Middle Tennessee @ Liberty | 5 | Liberty -20.5 (-110) | Win (+500) | |
| 10/09/2021 | Ball State @ Western Michigan | 4 | Ball State +12.5 (-110) | Win (+400) | |
| 10/09/2021 | SMU @ Navy | 5 | Over 57 (-110) | Loss (-550) | |
| 10/09/2021 | Michigan State @ Rutgers | 3 | Michigan State -4.5 (-105) | Win (+300) | |
| 10/09/2021 | Oklahoma @ Texas | 3 | Oklahoma -4 (-115) | Win (+300) | |
| 10/08/2021 | Stanford @ Arizona State | 4 | Over 51.5 (-110) | Loss (-440) | |
| 10/07/2021 | Coastal Carolina @ Arkansas State | 2 | Coastal Carolina -20.5 (-115) | Win (+200) | |
| 10/02/2021 | New Mexico State @ San Jose State | 2 | Under 52.5 (-110) | Loss (-220) | |
| 10/02/2021 | Liberty @ UAB | 1 | Over 49 (-110) | Loss (-110) | |
| 10/02/2021 | Southern Miss @ Rice | 5 | Rice -1 (-110) | Win (+500) | |
| 10/02/2021 | Texas Tech @ West Virginia | 4 | Over 55 (-110) | Loss (-440) | |
| 10/02/2021 | Central Michigan @ Miami-OH | 1 | Miami-OH +2 (-105) | Win (+100) | |
| 10/02/2021 | UCF @ Navy | 4 | Over 52.5 (-115) | Win (+400) | |
| 10/02/2021 | Louisiana-Monroe @ Coastal Carolina | 5 | Over 57.5 (-110) | Win (+500) | |
| 10/02/2021 | Louisiana-Monroe @ Coastal Carolina | 4 | Coastal Carolina -34 (-110) | Win (+400) | |
| 10/02/2021 | Pittsburgh @ Georgia Tech | 4 | Pittsburgh -3 (-110) | Win (+400) | |
| 10/02/2021 | Tennessee @ Missouri | 4 | Over 66.5 (-110) | Win (+400) | |
| 10/01/2021 | Houston @ Tulsa | 1 | Over 54 (-110) | Win (+100) | |
| 10/01/2021 | Houston @ Tulsa | 3 | Tulsa -3.5 (-110) | Loss (-330) | |
| 09/30/2021 | Virginia @ Miami-FL | 3 | Over 64 (-110) | Loss (-330) | |
| 09/25/2021 | Hawaii @ New Mexico State | 1 | New Mexico State +17 (-105) | Loss (-105) | |
| 09/25/2021 | UAB @ Tulane | 5 | Under 54.5 (-110) | Win (+500) | |
| 09/25/2021 | Florida Atlantic @ Air Force | 5 | Over 54 (-110) | Loss (-550) | |
| 09/25/2021 | Hawaii @ New Mexico State | 4 | Under 62.5 (-110) | Win (+400) | |
| 09/25/2021 | Southern Miss @ Alabama | 3 | Over 58.5 (-105) | Win (+300) | |
| 09/25/2021 | Louisiana-Lafayette @ Georgia Southern | 5 | Louisiana-Lafayette -14.5 (-110) | Loss (-550) | |
| 09/25/2021 | Miami-OH @ Army | 3 | Army -8 (-110) | Win (+300) | |
| 09/25/2021 | LSU @ Mississippi State | 3 | Over 55 (-110) | Loss (-330) | |
| 09/25/2021 | Boise State @ Utah State | 5 | Under 70 (-110) | Win (+500) | |
| 09/24/2021 | Wake Forest @ Virginia | 3 | Wake Forest +3.5 (-120) | Win (+300) | |
| 09/23/2021 | Marshall @ Appalachian State | 3 | Marshall +7.5 (-115) | Win (+300) | |
| 09/18/2021 | Arizona State @ BYU | 2 | Arizona State -3.5 (-110) | Loss (-220) | |
| 09/18/2021 | Stony Brook @ Oregon | 4 | Stony Brook +42 (-110) | Win (+400) | |
| 09/18/2021 | Incarnate Word @ Texas State | 3 | Incarnate Word +11 (-110) | Win (+300) | |
| 09/18/2021 | Charlotte @ Georgia State | 1 | Georgia State -4.5 (-105) | Win (+100) | |
| 09/18/2021 | Utah @ San Diego State | 4 | Utah -8 (-110) | Loss (-440) | |
| 09/18/2021 | South Carolina @ Georgia | 2 | Georgia -31.5 (-110) | Loss (-220) | |
| 09/18/2021 | Sacramento State @ California | 5 | California -27 (-110) | Loss (-550) | |
| 09/18/2021 | Georgia Southern @ Arkansas | 1 | Over 53 (-110) | Win (+100) | |
| 09/18/2021 | Colorado State @ Toledo | 1 | Colorado State +14.5 (-105) | Win (+100) | |
| 09/18/2021 | Georgia Tech @ Clemson | 5 | Clemson -28 (-110) | Loss (-550) | |
| 09/18/2021 | SMU @ LA Tech | 2 | SMU -12 (-115) | Loss (-230) | |
| 09/18/2021 | Tulsa @ Ohio State | 2 | Ohio State -25 (-110) | Loss (-220) | |
| 09/18/2021 | Eastern Michigan @ Massachusetts | 5 | Eastern Michigan -22 (-110) | Loss (-550) | |
| 09/18/2021 | Florida State @ Wake Forest | 4 | Over 62 (-110) | Loss (-440) | |
| 09/18/2021 | Delaware @ Rutgers | 1 | Rutgers -19.5 (-110) | Win (+100) | |
| 09/18/2021 | Purdue @ Notre Dame | 5 | Over 58 (-110) | Loss (-550) | |
| 09/18/2021 | Western Michigan @ Pittsburgh | 1 | Pittsburgh -15 (-110) | Loss (-110) | |
| 09/18/2021 | Chattanooga @ Kentucky | 1 | Over 48 (-110) | Win (+100) | |
| 09/18/2021 | Boston College @ Temple | 3 | Over 55.5 (-110) | Loss (-330) | |
| 09/18/2021 | UCONN @ Army | 3 | Over 47.5 (-110) | Win (+300) | |
| 09/11/2021 | Hawaii @ Oregon State | 1 | Under 65 (-110) | Loss (-110) | |
| 09/11/2021 | Stanford @ USC | 4 | Stanford +17 (-105) | Win (+400) | |
| 09/11/2021 | Utah @ BYU | 2 | Over 49.5 (-110) | Loss (-220) | |
| 09/11/2021 | San Diego State @ Arizona | 1 | Arizona -2 (-110) | Loss (-110) | |
| 09/11/2021 | Missouri @ Kentucky | 2 | Kentucky -6 (-105) | Win (+200) | |
| 09/11/2021 | Texas @ Arkansas | 2 | Over 56.5 (-110) | Win (+200) | |
| 09/11/2021 | Liberty @ Troy | 1 | Liberty -3 (-115) | Win (+100) | |
| 09/11/2021 | Eastern Michigan @ Wisconsin | 3 | Over 52 (-110) | Loss (-330) | |
| 09/11/2021 | Grambling State @ Southern Miss | 3 | Under 47.5 (-111) | Win (+300) | |
| 09/11/2021 | Liberty @ Troy | 4 | Over 62.5 (-110) | Loss (-440) | |
| 09/11/2021 | Hampton @ Old Dominion | 4 | Under 54.5 (-111) | Win (+400) | |
| 09/11/2021 | Stephen F. Austin @ Texas Tech | 1 | Stephen F. Austin +32 (-110) | Win (+100) | |
| 09/11/2021 | Houston @ Rice | 5 | Houston -7.5 (-110) | Win (+500) | |
| 09/11/2021 | South Carolina State @ Clemson | 5 | Clemson -50.5 (-110) | Loss (-550) | |
| 09/11/2021 | Rutgers @ Syracuse | 1 | Rutgers -3 (+100) | Win (+100) | |
| 09/11/2021 | Miami-OH @ Minnesota | 4 | Over 55 (-115) | Win (+400) | |
| 09/11/2021 | Miami-OH @ Minnesota | 1 | Minnesota -18 (-110) | Loss (-110) | |
| 09/11/2021 | Oregon @ Ohio State | 3 | Ohio State -14.5 (-115) | Loss (-345) | |
| 09/11/2021 | VMI @ Kent State | 1 | Kent State -19.5 (-110) | Win (+100) | |
| 09/10/2021 | UTEP @ Boise State | 3 | UTEP +26 (-115) | Loss (-345) | |
| 09/10/2021 | UTEP @ Boise State | 5 | Under 56.5 (-110) | Loss (-550) | |
| 09/06/2021 | Louisville @ Ole Miss | 1 | Ole Miss -10 (-110) | Win (+100) | |
| 09/05/2021 | Notre Dame @ Florida State | 5 | Under 55.5 (-110) | Loss (-550) | |
| 09/04/2021 | Nevada @ California | 2 | California -3.5 (-105) | Loss (-210) | |
| 09/04/2021 | LSU @ UCLA | 5 | Under 65 (-110) | Push (+0) | |
| 09/04/2021 | Southern Miss @ South Alabama | 1 | Over 56.5 (-110) | Loss (-110) | |
| 09/04/2021 | Southern Miss @ South Alabama | 5 | Southern Miss +1.5 (-110) | Loss (-550) | |
| 09/04/2021 | Montana @ Washington | 2 | Washington -24 (-110) | Loss (-220) | |
| 09/04/2021 | Tennessee-Martin @ WKU | 1 | WKU -24 (-110) | Win (+100) | |
| 09/04/2021 | East Tennessee State @ Vanderbilt | 3 | East Tennessee State +20 (-110) | Win (+300) | |
| 09/04/2021 | Baylor @ Texas State | 2 | Baylor -13.5 (-110) | Loss (-220) | |
| 09/04/2021 | Northern Iowa @ Iowa State | 3 | Iowa State -29.5 (-110) | Loss (-330) | |
| 09/04/2021 | Central Michigan @ Missouri | 2 | Missouri -14 (-110) | Loss (-220) | |
| 09/04/2021 | Marshall @ Navy | 5 | Marshall -3.5 (-105) | Win (+500) | |
| 09/04/2021 | Rice @ Arkansas | 2 | Arkansas -20 (-110) | Win (+200) | |
| 09/04/2021 | Rice @ Arkansas | 4 | Over 50 (-115) | Win (+400) | |
| 09/04/2021 | Tulane @ Oklahoma | 3 | Under 67.5 (-110) | Loss (-330) | |
| 09/04/2021 | Penn State @ Wisconsin | 3 | Wisconsin -5.5 (-110) | Loss (-330) | |
| 09/04/2021 | Fordham @ Nebraska | 1 | Nebraska -42.5 (-110) | Win (+100) | |
| 09/04/2021 | Holy Cross @ UCONN | 3 | Under 49.5 (-110) | Loss (-330) | |
| 09/03/2021 | St. Francis-PA @ Eastern Michigan | 1 | Over 55 (-110) | Loss (-110) | |
| 09/02/2021 | Weber State @ Utah | 4 | Over 49 (-109) | Win (+400) | |
| 08/28/2021 | Southern Utah @ San Jose State | 4 | Over 56.5 (-110) | Win (+400) | |
| 08/28/2021 | Southern Utah @ San Jose State | 2 | Southern Utah +24.5 (-105) | Loss (-210) | |
| 01/11/2021 | Ohio State Buckeyes @ Alabama Crimson Tide | 5 | Alabama Crimson Tide -8.75 (-110) | Win (+500) | |
| 01/02/2021 | Ole Miss @ Indiana | 1 | Ole Miss 8 (-110) | Win (+100) | |
| 01/02/2021 | Ole Miss @ Indiana | 4 | Over 67.5 (-110) | Loss (-440) | |
| 01/02/2021 | NC State @ Kentucky | 3 | Kentucky -3.5 (-110) | Loss (-330) | |
| 01/01/2021 | Notre Dame @ Alabama | 4 | Over 65.5 (-110) | Loss (-440) |